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KMID : 0356620160310010086
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Journal of Korean Society of Endocrinology
2016 Volume.31 No. 1 p.86 ~ p.92
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The Relationship between 10-Year Cardiovascular Risk Calculated Using the Pooled Cohort Equation and the Severity of Non-Alcoholic Fatty Liver Disease
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:Lee Jeong-In
:Kim Min-Chul/:Moon Byung-Sub/:Song Young-Seok/:Han Eun-Na/:Lee Hyo-Sun/:Son Yoon-Jeong/:Kim Ji-Hyun/:Han Eun-Jin/:Park Hye-Jeong/:Park Se-Eun/:Park Cheol-Young/:Lee Won-Young/:Oh Ki-Won/:Park Sung-Woo/:Rhee Eun-Jung
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Abstract
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Background : We investigated the association between the severity of non-alcoholic fatty liver disease (NAFLD) and the estimated 10-year risk of cardiovascular disease (CVD) calculated by Pooled Cohort Equation (PCE) and Framingham risk score (FRS).
Methods : A total of 15,913 participants (mean age, 46.3 years) in a health screening program were selected for analysis. The presence and severity of fatty liver was assessed by abdominal ultrasonogram. Subjects who drank alcohol more than three times a week were excluded from the study.
Results : Among the participants, 57.6% had no NAFLD, 35.4% had grade I, 6.5% had grade II, and 0.5% had grade III NAFLD. Mean estimated 10-year CVD risk was 2.59%, 3.93%, 4.68%, and 5.23% calculated using the PCE (P for trend <0.01) and 4.55%, 6.39%, 7.33%, and 7.13% calculated using FRS, according to NAFLD severity from none to severe (P for trend <0.01). The odds ratio for ≥7.5% estimated CVD risk calculated using the PCE showed a higher correlation with increasing severity of NAFLD even after adjustment for conventional CVD risk factors (1.52, 2.56, 3.35 vs. the no NAFLD group as a reference, P<0.01) compared with calculated risk using FRS (1.65, 1.62, 1.72 vs. no NAFLD group as a reference, P<0.01).
Conclusion : In our study of apparently healthy Korean adults, increasing severity of NAFLD showed a higher correlation with estimated 10-year CVD risk when calculated using the PCE than when calculated using FRS.
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KEYWORD
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Non-alcoholic fatty liver disease, Pooled Cohort Equation, Framingham risk score
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